Showing posts with label Bi Gu Fasting. Show all posts
Showing posts with label Bi Gu Fasting. Show all posts

Thursday, September 4, 2025

Reboot Your Body System Through Water Fast

 If you need 7-day , 14-day or 21-day water fast in New Zealand, please contact me.

I have been specially trained to be able to treat your particular pressure points in an amazing way to reduce the hunger and danger of water-fast.

Low cost accommodation is available for clients who would like to stay with me during water-fast.

Please listen to this doctor to understand how water-fast reset your system powerfully.

https://www.youtube.com/watch?v=jDG1m_b5Ih0


Monday, March 3, 2025

Some Interesting Comments on Bigu Fasting From Clients

 Some Interesting Comments From Clients


1.      “After my 14-day Bigu fasting,  I was finally convinced that Jesus’ fasting for 40 days was true.”

2.      “Now I believe that we human beings are not a physical body, we are light beings living in a physical body and able to live on invisible light nutrition.”

3.      “ I lost so much weight each day during Bigu that my mother was quite concerned about me!  However, I felt very excited to see the quick change in my body shape.”

4.      “After I lost so much weight, to my surprise, my skin was glowing and very smooth. None of my cosmetics has had this effect.”

5.      “I have naturally given up smoking after Bigu. I hadn’t expected to achieve this before I started Bigu.  My body and mind feel so pure and relaxed now and  just don’t need smoking anymore to feel better. ”

6.      “Bigu has naturally made me a vegetarian. It didn’t take any will power to achieve this. I have started to appreciate light and simple food now.”

7.      Two French, father and daughter, flew 24 hours and came to me for bigu treatments some years ago.

Their reasons to do bigu are:

a.      “We want to take a break from living on animals’ life and plants' life, so that the planet can have more chance to remain its natural look. Bigu will be good for both the planet and us.”

b.      “We would like to experience living on Light only and purify ourselves in order to be in better connection with God.”

c.      “We want to lose some weight.”

After 14-day Bigu, the father lost 11kgs, here are his comments: “Bigu is marvellous! I got very excited at my weight change each day when I stood on the scale. Now I feel very young, pure and brilliant. Bigu experience has convinced me that God is true. Bigu has so much changed my perspectives of life and the world.”
 The daughter said that she was able to feel energy flowing so smoothly in her body during bigu.

Saturday, January 7, 2023

Amazing Benefits of Bigu Fasting

We go on vacations from work to relax, recharge, and to gain new perspectives on our life; why not take regular breaks from food?

Bi Gu  Fasting is a powerful form of healing that has been practiced for thousands of years in China. It is a great way for eliminating toxins, healing diseases, losing weight and developing potential functions and wisdom. Bi Gu  Fasting is an ancient life-preservation method ,not simply starving yourself! It is different from the general practice of fasting. Bi Gu employs life preservation methods and special prayers to enhance one's capacity of opening to the invisible energies, which is nourishing and infinite. Bi Gu is gentle, safe and inspiring. With the assistance of powerful treatments on some pressure points , regular food can be safely replaced by water and invisible energies for 7-14 days.

When food is no longer entering the body, the body turns to fat and sugar reserves for energy, which brings forth natural healing and rapid weight-loss.
Bigu Fasting gives the digestive tract time to completely rest and heal itself. Instead of digesting food, more energy goes towards the metabolism, detoxification and immune system. The body's searching for energy sources leads to clean-up and natural healing. Abnormal growths within the body, harmful bacteria, weakened protein and the like, do not have the full support of the body's supplies and therefore are more susceptible to autolysis. The body rids itself of the toxins that have built up in our organs, tissues , blood and blood vessels throughout the years. The body heals itself, repairs all the damaged organs and cells during bigu fasting. It is just like turning off and cleaning a complex and valuable machine so that it will function better and longer.

Bigu fast is a multidimensional experience. Physiologically, refraining from eating minimizes the work done by the digestive organs, including the stomach, intestines, pancreas, gallbladder, and liver. Most important here is that our liver, our bodys large production and metabolic factory, can spend more time during fasting cleaning up and creating its many new substances for our use. Breakdown of stored or circulating fats and chemicals is the basic process of detoxification. The blood and lymph also have the opportunity to be cleaned of toxins as all the eliminative functions are enhanced with fasting. Each cell has the opportunity to catch up on its work; with fewer new demands, it can repair itself and dump its waste for the garbage pickup. Most Bigu students also experience a new vibrancy of their skin and clarity of mind and body.
We can look at Bigu fasting as "taking one or two weeks off work" to handle the other aspects of life, for which there is often little time. During Bigu, we can take time to rest and nurture ourselves. 

Resting the gastrointestinal tract, letting the cells and tissues repair themselves, and allowing the lymph, blood, and organs to clear out old, defective, or diseased cells and unneeded chemicals all lead to less degeneration and sickness. As healthy cell growth is stimulated, so is our level of vitality, immune function and disease resistance, and our potential for greater longevity.
Benefits of Bigu Fasting: Purification ; Rejuvenation; Quick weight-loss ; Rest for digestive organs ; Reduction of allergies ; Drug detoxification; A speedy recovery from chronic diseases; Normalize blood sugar level; Lower blood pressure and fat ;Reduction of the size and effect of tumors; Overcoming addictions; Better resistance to disease; Diet changes; More energy; Better sleep; Clearer skin ; Antiaging effects ;More relaxation; More mental clarity; Creativity;Clearer thinking ;Nice change of habits; Spiritual awareness.

 

If you are one of these 7 Kinds of People, you should consider Bi Gu:

1. have high blood pressure, high cholesterol and early stage diabetes

2.have Hepatitis, fatty liver, kidney stones, nephritis, gall stone, sinusitis, laryngitis, gastritis, intestinal inflammation, prostatis, arthritis, constipation;

3.have any of the following issues: overweight, acne, breast cyst, gynecological inflammation, infertility, uterine fibroid, ovarian cyst, painful menses hormonal imbalance, coarse skin and all kinds of skin diseases;

4. experience dizziness, fatigue, poor sleep, poor appetite, poor memory, low sexual function;

5. want to prepare for a healthy pregnancy and strong immune for mother and child

6. want to purify and keep body in good shape, enhance immune system, slow down aging process and keep young;

7.want to stay away from cancer and other serious diseases associated with aging.

Saturday, October 29, 2022

Bigu Fasting And Autophagy Theory That Won 2016 Nobel Prize

Bigu Fasting professional treatments enable a person to live safely on water and invisible energies for 1 to 3 weeks. This greatly promotes the process of Autophagy within a body's cells and purifies cells naturally.

Please open these two links to learn more about autophagy:

1.  

Mystery of life: Autophagy may open the door to longevity  from BBC

2. 

Mechanisms for autophagy: 2016 Nobel Prize in Physiology or Medicine

Monday, April 4, 2022

Fasting – Effective Therapy For Health Concerns (Written by a US doctor)

 "Most people’s experience tells them that going a day or two without solid food produces profound hunger and discomfort. The thought of going two or three weeks or longer without food leaves them incredulous, and certainly not eager to undertake such a trial. After supervising hundreds of fasts, many lasting 2-3 weeks, and some up to 30 or 40 days, I can report the happy news that reality is nothing like (much better than) the feared image people hold about fasting. 

How can this be?

For the first 24 to 48 hours after beginning a water fast, the body burns off circulating blood sugar and sugar stored in the muscles and liver in the form of glycogen. The “real” metabolic fast does not begin until one metabolizes their blood sugar, in approximately 2 to 3 days. At that time, the body begins to burn fat tissue for fuel. When that happens, molecules called ketones enter the blood circulation. These ketones have some very interesting properties.

For the faster, the main welcome property of ketones is that they suppress hunger. By day four or five of a water fast, hunger is usually gone and is replaced by a feeling of great well-being. 

Why more energy, and not less? 

So much of the energy that the body uses all day goes to digesting our food including muscular contractions of the intestine, chemical energy used to synthesize stomach acid, bile, and digestive enzymes as well as the billions of immune cells in the intestinal lining that interrogate the chemical nature of the food going by in the digestive tract. When that function is no longer required on a fast, all that energy is freed up and people surprisingly – but predictably – feel very light and energetic for the first several weeks on the fast.

It may be counterintuitive, but it is true nonetheless. The commonly-held image of a long water fast is of a person lying on their bed, weak, hungry and whimpering, trying not to think about food, when actually, the reality is quite the opposite.

People at our TrueNorth Health Center who are on a water fast, frequently stop me in our courtyard to say “Doctor, I haven’t felt this good in years! I haven’t eaten for three weeks, but I feel wonderful!” It really is quite remarkable. 

It is during this time that we observe a normalizing of blood pressure and blood sugar readings and a subsiding of most pains, swellings, and other signs of inflammation. (See corresponding references below.)

During a fast, the body is in “Full Energy Conservation Mode” and it does not want to spend precious chemical energy on chaotic, heat-generating, activities, such as inflammatory reactions and growing tumor tissue. During a fast, hot angry joints in rheumatoid arthritis, gout and other inflammatory joint diseases (predictably) cool down, inflamed plaques of psoriasis in the skin are becalmed, and wounds in and on the body heal extremely well. If malignant breast cells are multiplying in tissues, the fasting body generates molecules called sirtuins which put the breaks on cancer growth.

Water fasting cleanses the body on a deep, cellular level

All of us, in our body cells, have remnant molecules of every restaurant meal, fast food snack, and processed food dessert we have ever eaten. There are flavorings, colorings, preservatives, dough conditioners, stabilizers, and thousands of other compounds that compose a chemical soup of modern cuisine in all the cells in our body. These substances accumulate in our tissues over time, contributing to feelings of chronic fatigue and bodily dysfunction. 

A water fast has the effect of “taking your cells through the car wash” where day after day, nothing but pure water washes through each and every cell. This markedly lowers the concentrations of the foreign, disruptive molecules. 

Thus, it is no wonder that people predictably emerge from a water fast feeling lighter and cleaner on the inside because they really are."


To read the whole article, please click https://www.doctorklaper.com/fasting



Tuesday, February 22, 2022

Our service + Contact us

Service Website: 

https://wmnaturopathy.com

 WM Chinese Traditional Therapies & HealthCare

Welcome to this inspiring blogsite.

My name is Lan. As a professional Bigu Fasting therapist,  I am blessed to have mastered the unique traditional technique to help people easily enter into Bigu fasting state, safely Living on Divine Light Nutrition and Water for 7-14-21 days. For many years I have been providing this unique service in different cities and countries with full confidence. No Risks, No Medicines! It is like a cleansing surgery without scalpel! It has had thousands of history in China and become more and more popular with modern people who seek purity, balance and quality of life.

Bigu will prove that YOU ARE MUCH MORE Than A Physical Body. You will be safe and won't feel much sense of hunger after Bigu treatments, which involve pressing points and powerful prayers. All of these are conducted professionally in a particular state.  To maintain life processes during Bigu fasting, excess fat and sugar, weak and ill proteins, waste, toxins and abnormal growths in your body will burn off automatically, which benefits you in such ways: 

  •   Make you naturally lose weight each day and balance your body figure.
  •   Lower blood pressure, blood sugar and blood fat and uric acid naturally.
  •   Cleanse inside body “storage” holistically. This leads to self-healing from many chronic diseases.
  •  Improve the quality of skin by naturally reducing pimples and wrinkles.
  •  Purify your energy-field and tune you into deeper contact with divine energies for spiritual growth and profound inner peace.
  • Bring about a positive transformation that leads you to be free from any kind of addictions and start a healthier eating or drinking habit, since a purified body naturally feels like a light lifestyle.

     The unique treatments on pressure points are required for the first and last day of Bigu. Services that greatly benefit life are also available here, such as scraping massage treatment, healthcare, spiritual discussion, natural healing advice etc. 

For more Bigu Fasting infomation, please check through more articles in this blog.

Welcome to this life-transforming Bigu art to enjoy a refreshed life,  spiritual growth along with a slim body and a peaceful mind.

Please feel free to contact us to discuss these natural therapies with no obligation,  or book the services.

Service Website:  

https://wmnaturopathy.com

WM Chinese Traditional Therapies & HealthCare

Lan:0064-2108867169      

E-mail: gao1682@yahoo.com 

Sunday, February 13, 2022

Exciting Transformation That Happened To Bigu Fasting Man (With photos)


An IT professional, who loves yoga and healthy diet, undertook 14-day Bigu Fasting Regimen recently. To his surprise, he didn't feel hungry at all during the 14 days after the treatments on the points and being specially blessed. He was still able to work and do exercises while living on water only for so many days. He checked his own blood pressure on the 10th day and felt so pleased to see it at ideal level.

 Many unexpected great changes have taken place since his Bigu Fasting:

1.      He has lost 9kgs of weight.

2.      The wrinkles on his face and neck have reduced a lot naturally due to Bigu detoxing effect, which leads to better blood circulation.

3.      His skin quality improves considerably and he looks much younger than before.

4.      He is able to do highly difficult yoga postures freely now.

5.      His sweat isn't smelly anymore. 

Te   The swell on his finger has dissapeared unexpectedly.

       His nose isn't runny any more.

       He has overcome the habit of compulsive eating overnight.

 Before Bigu Fasting:



After Bigu Fasting:







Sunday, April 25, 2021

Frequently Asked Questions About Bigu Fasting

Frequently Asked Questions About Bigu Fasting

1.What are the differences between Bigu and Starving/Dieting?

Bigu: Gastric acid secretion is stopped by powerful treatments from Bigu instructor, which well protects your body and also prevents you from feeling hungry;

The potential invisible life system is activated by treatments, which enable your body to live on more advanced energies and make the metabolism normal , or even better during Bigu;

You are able to work normally and exercise normally. The second week of Bigu, you feel greatly refreshed and full of vitality.

After Bigu, you enjoy better circulation, feeling a lot healthier and more fulfilled. You naturally don’t feel like too much food or too heavy food anymore.


Starving/dieting:

Gastric acid secretion carries on, which causes strong sense of hunger and serious damages to the body.

Your body is cut off from source of energies.  

It is very likely that you feel like eating heavier meals after starving to make up for the lack of energies.


2.What do I eat or drink during Bigu?
You only need to drink pure water or light-flavoured herbal tea. Some simple meditation practice is required for feeling better. 

3.Do I need to stop working during Bigu? How long  should I do Bigu?
Mental workers and light physical workers are still able to work during Bigu and enjoy better clarity in thinking. 
How long for bigu depends on your goal. The recommendation is 14 days, which is safe and practicable for most people and gives best results. If you wish to get a more complete healing and rejuvenation, then you may follow your individual number of days or do 14-day Bigu regularly. 

4. Do I need to be strong in order to undertake Bigu?
There is no requirement to be physically strong to undertake bigu. Many high-performing bigu students had serious diseases, such as cancer, diabetes, hypertension, adiposis etc. In fact, the more unwell a person is, the more he or she needs bigu for holistic detox and self-healing.

5. How many kgs can I lose by bigu? What will happen if I'm skinny?

Bigu helps to cleanse and heal your whole digestive system ,which balances your weight and bodyfigure. Overweight people will naturally lose 5-20kgs of weight within 14 days. Because all the digestive organs will function much better in processing food after Bigu detox, your bodyfigure will be able to easily remain nice and balanced. 
Underweight people may gain some weight after bigu to reach a balance as 
digestive system will absorb nutrition in a healthy way after self-cleansing.
Your skin will be much smoother and give a nicer glow because blood will circulate much better than before Bigu.

6.Will Bigu help me break addictions or compulsive habits?
Yes, definitely . Addictions or compulsiveness are usually caused by physical blockage or mental stress. Once your body is holistically cleansed, the tension and stress within will be released,  you will feel so relaxed and so peaceful that you won't have to
 ease your nerves through any form of addiction. It is just a natural effect of Bigu, with no suffering or struggling.

7. How many times do I need to come to you and what do you do?
Three or more visits are required for the whole Bigu program. 
For the first visit, I press some points , activate your potential life system and teach simple practice for you to follow. The visits during bigu are for follow-up support. When you decide to finish Bigu fasting, you need to see me for points releasing and instrustion on how to eat again properly. In-between visits , we keep in contact by phone and I support you by praying for you everyday remotely. 

Wednesday, April 21, 2021

Amazing Effects of Bigu Fasting Retreat And Interesting Comments On Bigu

What will happen automatically when all your regular food is safely replaced by Divine Light Nutrition for 7 , 14 or  21 days?
The answer is:
A. You will be safe and won't feel sense of hunger after Bigu treatments, which involve pressing points and activating a new system. The gastric acid secretion and digestive system will be stopped during Bigu by the unique and powerful treatments;

B. This will give digestive organs time to rest and heal itself;
C. To maintain life processes, excess fat and sugar, weak proteins, toxins and some abnormal growths in your body will burn off automatically, which can
1. Make you naturally lose weight each day,
2. Lower blood pressure, blood sugar and fat and uric acid easily,
3. Cleanse inside body “storage” thoroughly and lead to self-healing from many chronic diseases;
D.This clean-up will purify your energy-field , raise your energy level and put you into deeper contact with divine universal energies for spiritual growth and profound inner peace,

E. Make it a natural transformation for you to start a healthier eating habit or be free from any type of addictions as a purified body naturally feels like lighter food or drink.

F. Bigu fasting experience and knowledge can help you survive any unexpected disaster or food crisis.
No risks! No medicines are involved at all! It is like a cleansing surgery without scalpel! 
The essence of life is Light. We human beings have the potential to live on water and light, just as plants do.  In fact, besides visible digestive system, there is an invisible system to sustain human life.  Let's think about food chain, light is absorbed by all kinds of plants while they are growing, then it enters into animals when animals eat plants; When we eat meat, grains or vegetables, it enters into our body to support life. Therefore, ultimately we are nurtured by light all the time, indirectly through food and directly through Bigu practice.

Bigu has had thousands of years' history in China. Spiritual seekers have been very keen on practising Bigu fasting to improve their energy levels. Bigu helps modern people achieve perfect figures and wonderful health.
What a marvelous idea it is to burn off all the negative energies built up in the body into energy to sustain life itself!
Given only 2 weeks, I will prove to you that all the benefits of Bigu fasting are true and genuine.

Most of modern diseases are the results of excess nutrient or pollutants in food.  Once a human body enters into Bigu state and cuts off the intake of food, it naturally shuts down its mouth, the portal for diseases and also provides no energy for weakened, aged, ill and abnormal cells and tissues. As a result, they are burned off automatically and naturally to sustain life. Excess sugar and fat is burned off in the first stage, then aged, weakened and ill proteins, lastly the waste and toxins in blood vessels and blood throughout a body. This is how Bigu results in natural weightloss and deep detox leading to self-healing.

Some comments on Bigu were made by a famous Chinese in a book.

“Bigu is a kind of practice that is for improving our quality of life and also provides many additional effects we need very much in our life.

(1) Bigu removes cause of cancer thoroughly and fundamentally. If one does bigu for three consecutive times, he won’t catch cancer and will keep healthy until the end of life.

(2) Bigu eliminates all sorts of toxins from the whole body, which results in self-healing from most diseases.

(3) Bigu helps people lose weight naturally. Many people do whatever it takes to get slim. Weight-loss is an inevitable effect of Bigu.

(4) Bigu gives wonderful beauty results that are hard to achieve in hospitals or beauty salons. After Bigu, skin improves considerably, facial pimples, spots and wrinkles gradually disappear.

(5) People’s memory and concentration level improve obviously after Bigu.

(6) Bigu sets people free from all kinds of addictions, such as drug, cigarette, alcohol, coffee. It is a natural process with no suffering and easily frees us from compulsion.

(7) Bigu has wonderful antiaging effect. It restores youth to the aged and reverses the functions of body by 20 years, therefore people feel much rejuvenated after Bigu.

Bigu is not for treating diseases, but it achieves most effective and rapid therapeutic effects. Bigu is an advanced method to eliminate toxins thoroughly and holisticly. ”

 


Fasting could help us cope with a number of diseases ( FASTING 'RESETS OUR BODIES' )

From :http://www.stuff.co.nz/life-style/well-good/inspire-me/67744102/fasting-could-help-us-cope-with-a-number-of-diseases

We usually think of fasting as a weight loss measure, but advocates say it has therapeutic benefits too.

Francoise Wilhelmi de Toledo combines a passion for her subject with a precision one would expect of a doctor and scientist with a raft of publications to her name.

"Real medicine is lifestyle. It is how we live," she says. "Drugs, any drugs, must be complementary to that."

As medical director of the renowned Buchinger Wilhelmi Clinic in Germany, she is an authority on therapeutic fasting and responsible at least in part for the current interest in its role in the management of chronic diseases including obesity, diabetes, high blood pressure, high cholesterol and cancer. And, of course, as a means of weight control made popular by the diet du jour, the 5:2.

The capacity to fast derives from periods when our ancestors ate more than they needed and built up fat reserves for winter when access to food was reduced.

Fasting – as part of a lifestyle – is undoubtedly a good thing, she says, but her focus is on making it part of the armamentarium available to doctors coping with an epidemic of lifestyle diseases in the West that threaten to cripple healthcare systems. 

She says there is strong evidence gathered over many decades to show how it can lower blood pressure, reduce excess fat and glucose in the blood, modulate the immune system, increase the effect of the mood and sleep-regulating neuro-transmitter serotonin, boost protein repair, and reduce inflammation.

Fasting has been likened to a "reset" button that returns the human body to its – healthy – factory settings. A study published last year in the United States, drawing on animal and human trials, concluded that three days of fasting can rejuvenate the immune system, triggering the production of new white blood cells. Other studies show that fasting can enable healthy cells to endure better the toxic impact of chemotherapy while cancer cells die more rapidly. It is a fascinating area of research that draws on the body's evolutionary adaptation.

"Human beings are not programmed for abundance," de Toledo says. "Humans are programmed for loss." The capacity to fast derives from periods when our ancestors ate more than they needed and built up fat reserves and surplus nutrients, such as vitamins and minerals, in summer and autumn.

In winter and spring, when access to food was much reduced, they endured periods of fasting in which their metabolism switched automatically from "external nutrition to nutrition taken from fat reserves".

In the absence of carbohydrates as a source of energy (glucose) for the cells, fatty acids, from fat supplies, were broken down in the liver to produce molecules known as ketone bodies which were used for fuel instead.

Of course we retain this ability to fast and exist on a ketogenic diet but rarely use it in the affluent West because food shortages are largely unknown. Nor is there much incentive to invest in fasting research, despite preliminary evidence that it may help in Parkinson's, multiple sclerosis and Alzheimer's. In Russia, there is a vast, largely unexplored archive built up by a psychiatrist Dr Yuri Nikolayev, who used fasting or "the hunger cure" to treat a range of mental disorders.

 

This lack of interest frustrates de Toledo.

"Take type 2 diabetes," she says. "This is a disease we know that we can cure [through fasting]. But there is an industry that sells all these drugs and devices. We have a type of medicine [in fasting] that is highly successful but there is no return on investment."

It was as a 17-year-old in Geneva that de Toledo embarked on her first fast with the aid of a book, because she "was at odds with my weight and wanted to match the ideal of the slim beauty". She says it was a revelation, that she felt "buoyant, sometimes euphoric" while fasting.

She says people who turn to fasting include some seeking help for intractable health problems while for others weight loss is the primary goal. Many, however, are seeking respite from stress of work in the "spiritual dimension of fasting" that de Toledo claims is one of its most beneficial side effects. 

She still fasts twice a year, during a 12-day annual retreat, and to counteract a severe seasonal allergy to birch pollen. She says suspicion and cynicism about fasting is still rife among doctors and nutritionists and she is determined to challenge it. "We want to document and show that fasting is therapeutically efficient, safe and enjoyable," she says.

The science, it would seem, is increasingly on her side.

 

Bigu Fasting Detox - Autophagy - 2016 Nobel Prize in Physiology or Medicine


https://www.sciencedaily.com/releases/2016/10/161003103237.htm

 

The Nobel Assembly at Karolinska Institutet has today decided to award the 2016 Nobel Prize in Physiology or Medicine to Yoshinori Ohsumi for his discoveries of mechanisms for autophagy.

Summary

This year's Nobel Laureate discovered and elucidated mechanisms underlying autophagy, a fundamental process for degrading and recycling cellular components.

The word autophagy originates from the Greek words auto-, meaning "self," and phagein, meaning "to eat"Thus,autophagy denotes "self eating." This concept emerged during the 1960's, when researchers first observed that the cell could destroy its own contents by enclosing it in membranes, forming sack-like vesicles that were transported to a recycling compartment, called the lysosome, for degradation. Difficulties in studying the phenomenon meant that little was known until, in a series of brilliant experiments in the early 1990's, Yoshinori Ohsumi used baker's yeast to identify genes essential for autophagy. He then went on to elucidate the underlying mechanisms for autophagy in yeast and showed that similar sophisticated machinery is used in our cells.

Ohsumi's discoveries led to a new paradigm in our understanding of how the cell recycles its content. His discoveries opened the path to understanding the fundamental importance of autophagy in many physiological processes, such as in the adaptation to starvation or response to infection. Mutations in autophagy genes can cause disease, and the autophagic process is involved in several conditions including cancer and neurological disease.

Degradation -- a central function in all living cells

In the mid 1950's scientists observed a new specialized cellular compartment, called an organelle, containing enzymes that digest proteins, carbohydrates and lipids. This specialized compartment is referred to as a "lysosome" and functions as a workstation for degradation of cellular constituents. The Belgian scientist Christian de Duve was awarded the Nobel Prize in Physiology or Medicine in 1974 for the discovery of the lysosome. New observations during the 1960's showed that large amounts of cellular content, and even whole organelles, could sometimes be found inside lysosomes. The cell therefore appeared to have a strategy for delivering large cargo to the lysosome. Further biochemical and microscopic analysis revealed a new type of vesicle transporting cellular cargo to the lysosome for degradation. Christian de Duve, the scientist behind the discovery of the lysosome, coined the term autophagy, "self-eating," to describe this process. The new vesicles were named autophagosomes.

During the 1970's and 1980's researchers focused on elucidating another system used to degrade proteins, namely the "proteasome." Within this research field Aaron Ciechanover, Avram Hershko and Irwin Rose were awarded the 2004 Nobel Prize in Chemistry for "the discovery of ubiquitin-mediated protein degradation." The proteasome efficiently degrades proteins one-by-one, but this mechanism did not explain how the cell got rid of larger protein complexes and worn-out organelles. Could the process of autophagy be the answer and, if so, what were the mechanisms?

A groundbreaking experiment

Yoshinori Ohsumi had been active in various research areas, but upon starting his own lab in 1988, he focused his efforts on protein degradation in the vacuole, an organelle that corresponds to the lysosome in human cells. Yeast cells are relatively easy to study and consequently they are often used as a model for human cells. They are particularly useful for the identification of genes that are important in complex cellular pathways. But Ohsumi faced a major challenge; yeast cells are small and their inner structures are not easily distinguished under the microscope and thus he was uncertain whether autophagy even existed in this organism. Ohsumi reasoned that if he could disrupt the degradation process in the vacuole while the process of autophagy was active, then autophagosomes should accumulate within the vacuole and become visible under the microscope. He therefore cultured mutated yeast lacking vacuolar degradation enzymes and simultaneously stimulated autophagy by starving the cells. The results were striking! Within hours, the vacuoles were filled with small vesicles that had not been degraded. The vesicles were autophagosomes and Ohsumi's experiment proved that authophagy exists in yeast cells. But even more importantly, he now had a method to identify and characterize key genes involved this process. This was a major break-through and Ohsumi published the results in 1992.

Autophagy genes are discovered

Ohsumi now took advantage of his engineered yeast strains in which autophagosomes accumulated during starvation. This accumulation should not occur if genes important for autophagy were inactivated. Ohsumi exposed the yeast cells to a chemical that randomly introduced mutations in many genes, and then he induced autophagy. His strategy worked! Within a year of his discovery of autophagy in yeast, Ohsumi had identified the first genes essential for autophagy. In his subsequent series of elegant studies, the proteins encoded by these genes were functionally characterized. The results showed that autophagy is controlled by a cascade of proteins and protein complexes, each regulating a distinct stage of autophagosome initiation and formation.

Autophagy -- an essential mechanism in our cells

After the identification of the machinery for autophagy in yeast, a key question remained. Was there a corresponding mechanism to control this process in other organisms? Soon it became clear that virtually identical mechanisms operate in our own cells. The research tools required to investigate the importance of autophagy in humans were now available.

Thanks to Ohsumi and others following in his footsteps, we now know that autophagy controls important physiological functions where cellular components need to be degraded and recycled. Autophagy can rapidly provide fuel for energy and building blocks for renewal of cellular components, and is therefore essential for the cellular response to starvation and other types of stress. After infection, autophagy can eliminate invading intracellular bacteria and viruses. Autophagy contributes to embryo development and cell differentiation. Cells also use autophagy to eliminate damaged proteins and organelles, a quality control mechanism that is critical for counteracting the negative consequences of aging.

Disrupted autophagy has been linked to Parkinson's disease, type 2 diabetes and other disorders that appear in the elderly. Mutations in autophagy genes can cause genetic disease. Disturbances in the autophagic machinery have also been linked to cancer. Intense research is now ongoing to develop drugs that can target autophagy in various diseases.

Autophagy has been known for over 50 years but its fundamental importance in physiology and medicine was only recognized after Yoshinori Ohsumi's paradigm-shifting research in the 1990's. For his discoveries, he is awarded this year's Nobel Prize in physiology or medicine.

Key publications

Takeshige, K., Baba, M., Tsuboi, S., Noda, T. and Ohsumi, Y. (1992). Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction. Journal of Cell Biology 119, 301-311

Tsukada, M. and Ohsumi, Y. (1993). Isolation and characterization of autophagy-defective mutants of Saccharomyces cervisiae. FEBS Letters 333, 169-174

Mizushima, N., Noda, T., Yoshimori, T., Tanaka, Y., Ishii, T., George, M.D., Klionsky, D.J., Ohsumi, M. and Ohsumi, Y. (1998). A protein conjugation system essential for autophagy. Nature 395, 395-398

Ichimura, Y., Kirisako T., Takao, T., Satomi, Y., Shimonishi, Y., Ishihara, N., Mizushima, N., Tanida, I., Kominami, E., Ohsumi, M., Noda, T. and Ohsumi, Y. (2000). A ubiquitin-like system mediates protein lipidation. Nature, 408, 488-492

Yoshinori Ohsumi was born 1945 in Fukuoka, Japan. He received a Ph.D. from University of Tokyo in 1974. After spending three years at Rockefeller University, New York, USA, he returned to the University of Tokyo where he established his research group in 1988. He is since 2009 a professor at the Tokyo Institute of Technology.


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